What Organs Are Affected by Lynch Syndrome? - medicinenet.com Aspirin can also have harmful side effects. National Library of Medicine Inheriting the faulty gene can increase your risk of developing cancer. Some people with Lynch syndrome may have a normal life expectancy if they can get appropriate monitoring and management of their cancer risk. Clinically relevant combined effect of polygenic background, rare pathogenic germline variants, and family history on colorectal cancer incidence. There is also an increased awareness that the clinical phenotype and cancer risk varies by specific mismatch repair mutation, which in turn has implications on surveillance strategies for patients. For a person with LS, the gene mutation they are born with means they may have a higher risk of developing certain types of cancer. Lynch syndrome causes a small percentage of all colorectal cancers, so health organizations such as the CDC feel that genetic testing will not provide additional benefits to people who have not received a diagnosis of colorectal cancer. People with LS may be offered surgery that removes healthy bowel as well as the area affected by cancer. Lynch syndrome follows an autosomal dominant inheritance pattern, in which a mutation needs to happen in only 1 copy of the gene for the person to have an increased risk of getting that disease. They will explain if you are likely to have a higher risk of cancer because of the pattern of cancer in your family. 2023 Mar 5;16(1):42. doi: 10.1186/s12920-023-01469-z. Lynch syndrome: Symptoms, treatment, and outlook - Medical Large Cancer Pedigree Involving Multiple Cancer Genes including Likely Digenic. Your risk is just much higher. A tumor can be benign (non-cancerous) or malignant (cancerous), which means it can spread to other parts of the body. Research has linked obesity to several different cancers, including: In a 2019 review article, researchers found a potential molecular link between obesity, insulin resistance, and colorectal cancer risk. Lynch syndrome is associated with an increased risk of cancer, especially cancer of the digestive system.

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