This retrospective matched cohort study explored the influence of adopting antagonist protocols that introduced LE during ovulation stimulation on trigger day on the hormone levels in infertile females undergoing IVF/ICSI. The month I conceived my progesterone level was 22.6. I hope this helps! We usually take this blood sample on day 21 of eCollection 2022. A progesterone level of 10 ng/ml considered as ovulatory. The conventional wisdom is that your progesterone levels should be at their higheston day 21 of your cycle. Prior to letrozole, my progesterone was really low, like single digits and never higher than mid-teens. progesterone Table1 Baseline characteristics of patients and the features of ovulation induction after propensity score matching. Besides progesterone levels on trigger day, four other variables were added to describe the changes in progesterone levels: 1) P1.5, i.e., the proportion of women with a progesterone level of >1.5 ng/ml. Grin L, Mizrachi Y, Cohen O, Lazer T, Liberty G, Meltcer S, et al. Although high levels of progesterone have been related to using LE during the luteal phase (15, 16), it remains unclear whether LE induces an increase in progestogen during the late follicular phase. This month I had two dominant follicles 7.5 mg of Femara and progesterone came back at 22.6. The dose of LET should be increased to 5 mg and then 7.5 mg/day in subsequent cycles in cases of absent ovarian response. In PSM 2 cohort, patients in the LE GnRH-a group presented higher progesterone levels on trigger day (1.23 0.91 ng/mL vs 0.98 0.61 ng/mL, P < 0.001), with a higher proportion of patients with progesterone level > 1.5 ng/mL (25.45% vs 12.70%, P < 0.001). 8600 Rockville Pike Shufaro Y, Sapir O, Oron G, Ben Haroush A, Garor R, Pinkas H, et al. Among women with PCOS, especially those with obesity, letrozole may work better. Simultaneously, the proportion of patients with a progesterone level >1.5 ng/mL was 3.70 times higher in the LE GnRH-ant group. Progesterone levels of > 1.5 ng/mL on trigger day can affect the results of embryo transfer, and it is recommended to freeze all embryos before transferring (21). Before Age, duration of infertility, body mass index (BMI), anti-Mullerian hormone (AMH) levels during menstruation, factors of infertility, and treatment intervention features (including total gonadotropins, stimulation days, total retrieved oocytes, and hormone levels on trigger day) were collected from the hospitals medical record system. Figure2 Relationship between progesterone levels and the number of retrieved oocytes in GnRH-ant and LE GnRH-ant groups. When the lead follicle was 14 mm or more in diameter or oestradiol levels were 400 pg/mL, patients received 0.25 mg of antagonist (Cetrotide; Merk Serono, Switzerland) until they were triggered by hCG (Chorionic Gonadotrophin, Lizhu, China). 7 Sources By Michelle Pugle Progesterone is released from the pituitary gland in pulses, meaning that progesterone levels can vary widely (up to 8-fold!) Curr Opin Obstet Gynecol. Eur Rev Med Pharmacol Sci (2017) 13:31348. Premature LH surge may lead to an increase in progesterone and also result in early ovulation. Yang X, Lin G, Lu G, Gong F. Letrozole Supplementation During Controlled Ovarian Stimulation in Expected High Responders: A Pilot Randomized Controlled Study. Haukoos JS, Lewis RJ. WebWhat should progesterone level be on day 21? Scenario: Management | Management | Infertility | CKS | NICE

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